Title : Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse.

Pub. Date : 2004 Jul 13

PMID : 15240880






1 Functional Relationships(s)
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1 Here we show that overexpression of suppressors of cytokine signaling (SOCS)-1 and SOCS-3 in liver causes insulin resistance and an increase in the key regulator of fatty acid synthesis in liver, sterol regulatory element-binding protein (SREBP)-1c. Fatty Acids sterol regulatory element binding transcription factor 1 Mus musculus