Title : Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest.

Pub. Date : 2004 Jul 1

PMID : 15231658






4 Functional Relationships(s)
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1 The IC(50) concentration of C-1305 determined for PARP-1 knockout cells was approximately 150-fold lower than that determined for cells with functional PARP-1. C 1305 poly (ADP-ribose) polymerase family, member 1 Mus musculus
2 The IC(50) concentration of C-1305 determined for PARP-1 knockout cells was approximately 150-fold lower than that determined for cells with functional PARP-1. C 1305 poly (ADP-ribose) polymerase family, member 1 Mus musculus
3 C-1305 strongly affected cell cycle progression in normal and PARP-1 mutant cells and arrested both cell types in G(2)-M phase. C 1305 poly (ADP-ribose) polymerase family, member 1 Mus musculus
4 Together, these results show that mouse cells lacking PARP-1 are extremely sensitive to C-1305, a new topoisomerase II inhibitor. C 1305 poly (ADP-ribose) polymerase family, member 1 Mus musculus