Pub. Date : 2004 Aug 27
PMID : 15220355
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Herein we utilized deletion constructs encoding two different functional domains of Akt/PKB to identify which region of the enzyme conferred responsiveness to ceramide. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Surprisingly the findings obtained with these separate domains reveal that ceramide blocks insulin stimulation of Akt/PKB by two independent mechanisms. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Surprisingly the findings obtained with these separate domains reveal that ceramide blocks insulin stimulation of Akt/PKB by two independent mechanisms. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | First, using the isolated pleckstrin homology domain, we found that ceramide specifically blocks the translocation of Akt/PKB, but not its upstream activator phosphoinositide-dependent kinase-1, to the plasma membrane. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | Second, using a construct lacking this pleckstrin homology domain, which does not require translocation for activation, we found that ceramide stimulates the dephosphorylation of Akt/PKB by protein phosphatase 2A. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 8 | Second, using a construct lacking this pleckstrin homology domain, which does not require translocation for activation, we found that ceramide stimulates the dephosphorylation of Akt/PKB by protein phosphatase 2A. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 9 | Moreover the results obtained provide a unifying theory to account for the numerous dissenting reports investigating the actions of ceramide toward Akt/PKB. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |