PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15220355-0	2004	Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.	Ceramides	32-40	AKT serine/threonine kinase 1	Homo sapiens	109-112	
15220355-0	2004	Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.	Ceramides	66-74	AKT serine/threonine kinase 1	Homo sapiens	109-112	
15220355-3	2004	Herein we utilized deletion constructs encoding two different functional domains of Akt/PKB to identify which region of the enzyme conferred responsiveness to ceramide.	Ceramides	159-167	AKT serine/threonine kinase 1	Homo sapiens	84-91	
15220355-4	2004	Surprisingly the findings obtained with these separate domains reveal that ceramide blocks insulin stimulation of Akt/PKB by two independent mechanisms.	Ceramides	75-83	AKT serine/threonine kinase 1	Homo sapiens	114-117	
15220355-4	2004	Surprisingly the findings obtained with these separate domains reveal that ceramide blocks insulin stimulation of Akt/PKB by two independent mechanisms.	Ceramides	75-83	AKT serine/threonine kinase 1	Homo sapiens	118-121	
15220355-5	2004	First, using the isolated pleckstrin homology domain, we found that ceramide specifically blocks the translocation of Akt/PKB, but not its upstream activator phosphoinositide-dependent kinase-1, to the plasma membrane.	Ceramides	68-76	AKT serine/threonine kinase 1	Homo sapiens	118-125	
15220355-6	2004	Second, using a construct lacking this pleckstrin homology domain, which does not require translocation for activation, we found that ceramide stimulates the dephosphorylation of Akt/PKB by protein phosphatase 2A.	Ceramides	134-142	AKT serine/threonine kinase 1	Homo sapiens	179-182	
15220355-6	2004	Second, using a construct lacking this pleckstrin homology domain, which does not require translocation for activation, we found that ceramide stimulates the dephosphorylation of Akt/PKB by protein phosphatase 2A.	Ceramides	134-142	AKT serine/threonine kinase 1	Homo sapiens	183-186	
15220355-8	2004	Moreover the results obtained provide a unifying theory to account for the numerous dissenting reports investigating the actions of ceramide toward Akt/PKB.	Ceramides	132-140	AKT serine/threonine kinase 1	Homo sapiens	148-155