Title : Identification of non-phosphate-containing small molecular weight inhibitors of the tyrosine kinase p56 Lck SH2 domain via in silico screening against the pY + 3 binding site.

Pub. Date : 2004 Jul 1

PMID : 15214778






1 Functional Relationships(s)
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1 The 34 out of 196 computationally selected compounds were shown to inhibit Lck SH2 domain association with phosphorylated immunoreceptor tyrosine based activation motifs peptide. Tyrosine LCK proto-oncogene, Src family tyrosine kinase Homo sapiens