Title : Heparin enhances active site-dependent binding of tissue-type plasminogen activator to endothelial cells.

Pub. Date : 1992 Sep 15

PMID : 1520875






3 Functional Relationships(s)
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Protein Name
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1 Several results suggested that heparin increased the binding of rt-PA to "cell-associated" PAI-1. Heparin serpin family E member 1 Homo sapiens
2 Second, extracts from HUVEC preincubated with heparin contained increased amounts of rt-PA-PAI-1 complexes as shown by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Heparin serpin family E member 1 Homo sapiens
3 Therefore, heparin, at therapeutic concentrations, may enhance or stabilize the association of PAs with endothelial cell-associated PAI-1. Heparin serpin family E member 1 Homo sapiens