Title : A monoclonal antibody-beta-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer.

Pub. Date : 1992 Sep

PMID : 1520585






2 Functional Relationships(s)
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1 Pretreatment of antigen-positive cells with the 323/A3-GUS conjugate prior to prodrug exposure completely restored cytotoxicity as a result from hydrolysis of Epi-glu into Epi. Glutamic Acid glucuronidase beta Homo sapiens
2 Our results demonstrate that the 323/A3-GUS conjugate can specifically activate the stable non-toxic prodrug Epi-glu at the tumour cell level. Glutamic Acid glucuronidase beta Homo sapiens