Title : Cooperative function of Chk1 and p38 pathways in activating G2 arrest following exposure to temozolomide.

Pub. Date : 2004 Jun

PMID : 15200121






2 Functional Relationships(s)
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1 The p38 inhibitor SB203580 or the Chk1 inhibitor UCN-01 or their combination blocked TMZ-mediated inactivation of cdc25C and cdc2, suggesting that p38 and Chk1 pathways work cooperatively and are both necessary to inactivate cdc25C and cdc2. 7-hydroxystaurosporine cyclin dependent kinase 1 Homo sapiens
2 The p38 inhibitor SB203580 or the Chk1 inhibitor UCN-01 or their combination blocked TMZ-mediated inactivation of cdc25C and cdc2, suggesting that p38 and Chk1 pathways work cooperatively and are both necessary to inactivate cdc25C and cdc2. 7-hydroxystaurosporine cyclin dependent kinase 1 Homo sapiens