Title : Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors.

Pub. Date : 2004 Aug 12

PMID : 15184865






1 Functional Relationships(s)
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1 Substitution of valine 804 with the small amino- acid glycine renders the RET kinase even more susceptible to inhibition (ZD6474 IC(50): 20 nM) than the wild-type kinase. Glycine ret proto-oncogene Homo sapiens