Title : Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation.

Pub. Date : 2004 Aug 20

PMID : 15169778






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Stimulation of human embryonic kidney 293 cells with insulin-like growth factor-1 increased Mdm2 phosphorylation on Ser(166) and Ser(188) in a phosphatidylinositide 3"-OH kinase-dependent manner, and the treatment of both human embryonic kidney 293 and COS-1 cells with phosphatidylinositide 3"-OH kinase inhibitor LY-294002 led to proteasome-mediated Mdm2 degradation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one MDM2 proto-oncogene Homo sapiens