Title : Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.

Pub. Date : 2004 Jun

PMID : 15169628






1 Functional Relationships(s)
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1 Measurements of cyclin A and B protein levels, Cdk2 and Cdc2 kinase activities, Cdc25C phosphorylation, and Chk1 kinase activity were consistent with UCN-01-induced abrogation of the S/G2-phase checkpoint in ara-C treated cells. 7-hydroxystaurosporine cyclin dependent kinase 1 Homo sapiens