Title : Leukotriene A4 hydrolase, a bifunctional enzyme. Distinction of leukotriene A4 hydrolase and aminopeptidase activities by site-directed mutagenesis at Glu-297.

Pub. Date : 1992 Sep 14

PMID : 1516710






3 Functional Relationships(s)
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1 Distinction of leukotriene A4 hydrolase and aminopeptidase activities by site-directed mutagenesis at Glu-297. Glutamic Acid leukotriene A4 hydrolase Homo sapiens
2 Thus, Glu-297 of LTA4 hydrolase is a candidate for the active site of its aminopeptidase activity, while His-296, His-300 and Glu-319 appear to constitute a zinc binding site. Glutamic Acid leukotriene A4 hydrolase Homo sapiens
3 The mutant E297Q (Glu changed to Gln) conserved LTA4 hydrolase activity but showed little aminopeptidase activity. Glutamic Acid leukotriene A4 hydrolase Homo sapiens