Pub. Date : 2004 Jul
PMID : 15158089
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia. | Semaxinib | fms related receptor tyrosine kinase 3 | Homo sapiens |
| 2 | SU5416 is a small molecule inhibitor of VEGF receptors, c-kit and FLT3 and therefore provides a novel opportunity to target both angiogenesis and proliferation in AML. | Semaxinib | fms related receptor tyrosine kinase 3 | Homo sapiens |
| 3 | Since AML provides a unique platform to evaluate mechanism of action of small molecule inhibitors, investigation of the effect of SU5416 on FLT3 expression and phosphorylation in blood and bone marrow was an additional focus of this trial. | Semaxinib | fms related receptor tyrosine kinase 3 | Homo sapiens |
| 4 | Phosphorylated FLT3 was detected by immunoprecipitation/Western analysis in peripheral blood samples from 17 of 22 patients, and seven exhibited strong inhibition of phosphorylation immediately following a 1h SU5416 infusion, demonstrating that SU5416 can modulate RTK phosphorylation in humans. | Semaxinib | fms related receptor tyrosine kinase 3 | Homo sapiens |
| 5 | Phosphorylated FLT3 was detected by immunoprecipitation/Western analysis in peripheral blood samples from 17 of 22 patients, and seven exhibited strong inhibition of phosphorylation immediately following a 1h SU5416 infusion, demonstrating that SU5416 can modulate RTK phosphorylation in humans. | Semaxinib | fms related receptor tyrosine kinase 3 | Homo sapiens |
| 6 | Although no clear correlation with clinical response was observed, analysis of patient plasma drug levels suggested that a threshold SU5416 concentration of 15 microM was associated with FLT3 inhibition. | Semaxinib | fms related receptor tyrosine kinase 3 | Homo sapiens |