Pub. Date : 2004 Jun
PMID : 15151944
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Breast cancer cell lines expressing a constitutively active Akt are able to proliferate under reduced estrogen conditions, and are resistant to the growth inhibitory effects of tamoxifen. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Understanding the targets of Akt signaling mediating tamoxifen resistance is of clinical significance. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In the present study, we found that Akt activity correlated with phosphorylation of I kappa B (the negative regulator of NF-kappa B), NF-kappa B DNA binding and tamoxifen resistance in vivo. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Importantly, we found that co-treatment with the NF-kappa B inhibitor, parthenolide, or overexpression of I kappa B superrepressor restored tamoxifen sensitivity to our refractory Akt MCF-7 cells. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |