PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15151944-2	2004	Breast cancer cell lines expressing a constitutively active Akt are able to proliferate under reduced estrogen conditions, and are resistant to the growth inhibitory effects of tamoxifen.	Tamoxifen	177-186	AKT serine/threonine kinase 1	Homo sapiens	60-63	
15151944-3	2004	Understanding the targets of Akt signaling mediating tamoxifen resistance is of clinical significance.	Tamoxifen	53-62	AKT serine/threonine kinase 1	Homo sapiens	29-32	
15151944-5	2004	In the present study, we found that Akt activity correlated with phosphorylation of I kappa B (the negative regulator of NF-kappa B), NF-kappa B DNA binding and tamoxifen resistance in vivo.	Tamoxifen	161-170	AKT serine/threonine kinase 1	Homo sapiens	36-39	
15151944-6	2004	Importantly, we found that co-treatment with the NF-kappa B inhibitor, parthenolide, or overexpression of I kappa B superrepressor restored tamoxifen sensitivity to our refractory Akt MCF-7 cells.	Tamoxifen	140-149	AKT serine/threonine kinase 1	Homo sapiens	180-183