Title : D-glucose triggers multidrug resistance-associated protein (MRP)-mediated secretion of fluorescein across rat jejunum in vitro.

Pub. Date : 2004 Apr

PMID : 15139520






9 Functional Relationships(s)
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1 D-glucose triggers multidrug resistance-associated protein (MRP)-mediated secretion of fluorescein across rat jejunum in vitro. Fluorescein ATP binding cassette subfamily C member 2 Rattus norvegicus
2 D-glucose triggers multidrug resistance-associated protein (MRP)-mediated secretion of fluorescein across rat jejunum in vitro. Fluorescein ATP binding cassette subfamily C member 2 Rattus norvegicus
3 PURPOSE: To examine the transport characteristics of the multidrug resistance-associated protein (MRP) substrate fluorescein across the isolated rat small intestinal segments. Fluorescein ATP binding cassette subfamily C member 2 Rattus norvegicus
4 PURPOSE: To examine the transport characteristics of the multidrug resistance-associated protein (MRP) substrate fluorescein across the isolated rat small intestinal segments. Fluorescein ATP binding cassette subfamily C member 2 Rattus norvegicus
5 The polarization of fluorescein transport was almost completely abolished by MRP inhibitor, benzbromarone (50 or 100 microM, applied apically), and by MRP/P-glycoprotein inhibitor, verapamil (200 microM, applied apically). Fluorescein ATP binding cassette subfamily C member 2 Rattus norvegicus
6 The polarization of fluorescein transport was almost completely abolished by MRP inhibitor, benzbromarone (50 or 100 microM, applied apically), and by MRP/P-glycoprotein inhibitor, verapamil (200 microM, applied apically). Fluorescein ATP binding cassette subfamily C member 2 Rattus norvegicus
7 CONCLUSIONS: D-glucose at the mucosal side activates fluorescein secretion across rat jejunum by an apical MRP, most probably by isoform 2 (MRP2), which could have an impact on the intestinal absorption of MRP substrates. Fluorescein ATP binding cassette subfamily C member 2 Rattus norvegicus
8 CONCLUSIONS: D-glucose at the mucosal side activates fluorescein secretion across rat jejunum by an apical MRP, most probably by isoform 2 (MRP2), which could have an impact on the intestinal absorption of MRP substrates. Fluorescein ATP binding cassette subfamily C member 2 Rattus norvegicus
9 CONCLUSIONS: D-glucose at the mucosal side activates fluorescein secretion across rat jejunum by an apical MRP, most probably by isoform 2 (MRP2), which could have an impact on the intestinal absorption of MRP substrates. Fluorescein ATP binding cassette subfamily C member 2 Rattus norvegicus