Title : No need to be HAMLET or BAMLET to interact with histones: binding of monomeric alpha-lactalbumin to histones and basic poly-amino acids.

Pub. Date : 2004 May 18

PMID : 15134431






2 Functional Relationships(s)
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1 The ability of a specific complex of human alpha-lactalbumin with oleic acid (HAMLET) to induce cell death with selectivity for tumor and undifferentiated cells was shown recently to be mediated by interaction of HAMLET with histone proteins irreversibly disrupting chromatin structure [Duringer, C., et al. Oleic Acid lactalbumin alpha Homo sapiens
2 Thus, the modification of alpha-LA by oleic acid is not required for binding to histones. Oleic Acid lactalbumin alpha Homo sapiens