Title : The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling.

Pub. Date : 2004 Jul 9

PMID : 15133037






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In response to epidermal growth factor (EGF), SHP-2 associates via its SH2 domains with tyrosyl-phosphorylated MVP. cyclo(tyrosyl-tyrosyl) protein tyrosine phosphatase non-receptor type 11 Homo sapiens
2 MVP also interacts with the activated form of the extracellular-regulated kinases (Erks) in response to EGF and a constitutive complex between tyrosyl-phosphorylated MVP, SHP-2, and the Erks was detected in MCF-7 breast cancer cells. cyclo(tyrosyl-tyrosyl) protein tyrosine phosphatase non-receptor type 11 Homo sapiens
3 The regulation of MVP tyrosyl phosphorylation by SHP-2 may play an important role in cell survival signaling. cyclo(tyrosyl-tyrosyl) protein tyrosine phosphatase non-receptor type 11 Homo sapiens