Title : Characterization of atrazine biotransformation by human and murine glutathione S-transferases.

Pub. Date : 2004 Aug

PMID : 15115887






2 Functional Relationships(s)
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1 Using recombinant alpha, mu, pi and theta class human GSTs, we demonstrated that only hGSTP1-1 displays significant activity toward atrazine (7.1 nmol/min/mg protein). Atrazine glutathione S-transferase pi 1 Homo sapiens
2 Docking studies of the atrazine-GST conjugate in the hGSTP1-1 substrate-binding site were used to elucidate a basis for the dramatic difference in activity between mouse GSTP1-1 and GSTP2-2 (7.14 versus 0.02 nmol/min/mg protein, respectively). Atrazine glutathione S-transferase pi 1 Homo sapiens