Title : Effects of dialkoxylphenyl compounds with oxime group on macrophage function and the proliferation of lymphocytes.

Pub. Date : 2004 Apr

PMID : 15099445






2 Functional Relationships(s)
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1 The structure-activity relationship (SAR) study with 12 compounds on tumour necrosis factor (TNF)-alpha inhibition, analysed by the oxime geometry and different size of spacers between the oxime and phenyl group, indicated that there might be at least three possible hydrogen bonding sites in the inhibitor binding pocket of PDE IV. Oximes tumor necrosis factor Mus musculus
2 The structure-activity relationship (SAR) study with 12 compounds on tumour necrosis factor (TNF)-alpha inhibition, analysed by the oxime geometry and different size of spacers between the oxime and phenyl group, indicated that there might be at least three possible hydrogen bonding sites in the inhibitor binding pocket of PDE IV. Oximes tumor necrosis factor Mus musculus