Pub. Date : 2004 Apr 19
PMID : 15096541
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation. | Cyclic AMP | PML nuclear body scaffold | Homo sapiens |
| 2 | Directly probing PML-RARA function in APL cells, we found that the differentiation enhancer cyclic AMP (cAMP) boosted transcriptional activation by RA. | Cyclic AMP | PML nuclear body scaffold | Homo sapiens |
| 3 | Directly probing PML-RARA function in APL cells, we found that the differentiation enhancer cyclic AMP (cAMP) boosted transcriptional activation by RA. | Cyclic AMP | PML nuclear body scaffold | Homo sapiens |
| 4 | cAMP also reversed the normal silencing (subordination) of the transactivating function of RXR when bound to RARA or PML-RARA, demonstrating that the alternate rexinoid/cAMP-triggered APL differentiation pathway also activates PML-RARA targets. | Cyclic AMP | PML nuclear body scaffold | Homo sapiens |
| 5 | cAMP also reversed the normal silencing (subordination) of the transactivating function of RXR when bound to RARA or PML-RARA, demonstrating that the alternate rexinoid/cAMP-triggered APL differentiation pathway also activates PML-RARA targets. | Cyclic AMP | PML nuclear body scaffold | Homo sapiens |
| 6 | cAMP also reversed the normal silencing (subordination) of the transactivating function of RXR when bound to RARA or PML-RARA, demonstrating that the alternate rexinoid/cAMP-triggered APL differentiation pathway also activates PML-RARA targets. | Cyclic AMP | PML nuclear body scaffold | Homo sapiens |
| 7 | Finally, cAMP restored both RA-triggered differentiation and PML-RARA transcriptional activation in mutant RA-resistant APL cells. | Cyclic AMP | PML nuclear body scaffold | Homo sapiens |