Title : Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1.

Pub. Date : 2004 May 1

PMID : 15093734






2 Functional Relationships(s)
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1 In this study, chemical and physiological hypoxia, which were shown to induce HIF-1alpha stabilization and HIF-1 activation, were shown to inhibit apoptosis induced in HepG2 cells by two different pro-apoptotic conditions, serum deprivation- and t-BHP-induced oxidative stress. tert-Butylhydroperoxide hypoxia inducible factor 1 subunit alpha Homo sapiens
2 In this study, chemical and physiological hypoxia, which were shown to induce HIF-1alpha stabilization and HIF-1 activation, were shown to inhibit apoptosis induced in HepG2 cells by two different pro-apoptotic conditions, serum deprivation- and t-BHP-induced oxidative stress. tert-Butylhydroperoxide hypoxia inducible factor 1 subunit alpha Homo sapiens