Pub. Date : 2004 Jun
PMID : 15081797
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We wanted to elucidate the role of the adenosine A(1) receptor (A1R) in mediating the locomotor effects of increasing doses of caffeine using wild-type mice (A1R(WT)), mice heterozygous for (A1R(HET)), and mice lacking the adenosine A(1) receptor (A1R(KO)). | Caffeine | adenosine A1 receptor | Mus musculus |
2 | We wanted to elucidate the role of the adenosine A(1) receptor (A1R) in mediating the locomotor effects of increasing doses of caffeine using wild-type mice (A1R(WT)), mice heterozygous for (A1R(HET)), and mice lacking the adenosine A(1) receptor (A1R(KO)). | Caffeine | adenosine A1 receptor | Mus musculus |
3 | Caffeine had the typical biphasic dose-effect relationship in all three genotypes, but the stimulatory action of caffeine was facilitated in the A1R(KO) mice. | Caffeine | adenosine A1 receptor | Mus musculus |
4 | As expected, the A1R is not crucial for the stimulatory effect of caffeine, but seems to modulate the effect of caffeine exerted via A2AR blockade. | Caffeine | adenosine A1 receptor | Mus musculus |