Pub. Date : 2004 Sep
PMID : 15073047
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OGG1 protein has an ability to suppress mutagenesis induced by 8-hydroxyguanine (8OHG), an oxidatively damaged promutagenic base. | 8ohg | 8-oxoguanine DNA glycosylase | Homo sapiens |
| 2 | Here, the mutation suppressive ability was compared between two common polymorphic OGG1 proteins, OGG1-Ser326 and OGG1-Cys326, using a supF forward mutation assay employing an 8OHG-containing plasmid. | 8ohg | 8-oxoguanine DNA glycosylase | Homo sapiens |
| 3 | Mutations by 8OHG were more efficiently suppressed in OGG1-Ser326 transduced cells than OGG1-Cys326 transduced cells. | 8ohg | 8-oxoguanine DNA glycosylase | Homo sapiens |
| 4 | The results indicated that OGG1-Cys326 has a lower ability to prevent mutagenesis by 8OHG than OGG1-Ser326 in vivo in human cells; supporting the results of recent association studies that OGG1-Cys326 is a risk allele for several types of human cancers. | 8ohg | 8-oxoguanine DNA glycosylase | Homo sapiens |