Title : Tamoxifen modulation of etoposide cytotoxicity involves inhibition of protein kinase C activity and insulin-like growth factor II expression in brain tumor cells.

Pub. Date : 2004 Mar-Apr

PMID : 15072444






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Tamoxifen modulation of etoposide cytotoxicity involves inhibition of protein kinase C activity and insulin-like growth factor II expression in brain tumor cells. Tamoxifen insulin like growth factor 2 Homo sapiens
2 While P-gp, IGF-IR and IGF-I were not affected, enhanced inhibition of PKC, and IGF-II were observed in brain tumor cells treated with tamoxifen and etoposide combination as compared to cells treated with either drug alone. Tamoxifen insulin like growth factor 2 Homo sapiens
3 These results suggest that inhibitory effect of tamoxifen on brain tumor cells manifest through different mechanisms involving inhibition of targets such as PKC and IGF-II. Tamoxifen insulin like growth factor 2 Homo sapiens