Pub. Date : 2004 Apr
PMID : 15066664
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we have synthesized novel alpha-hydroxyphenylamide analogues of diphenylhydantoin and examined their ability to inhibit human Na(V)1.5 sodium channels expressed in Chinese Hamster Ovary (CHO-K1) cells. | Phenytoin | immunoglobulin lambda variable 2-18 | Homo sapiens |
| 2 | In comparison to diphenylhydantoin, the novel chloro-substituted alpha-hydroxyphenylamide compounds produced as much as a 20-fold greater tonic and frequency-dependent blockade of Na(V)1.5 channels with an IC(50) value of 14.5 microM. | Phenytoin | immunoglobulin lambda variable 2-18 | Homo sapiens |