PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15066664-3 2004 In this study, we have synthesized novel alpha-hydroxyphenylamide analogues of diphenylhydantoin and examined their ability to inhibit human Na(V)1.5 sodium channels expressed in Chinese Hamster Ovary (CHO-K1) cells. Phenytoin 79-96 immunoglobulin lambda variable 2-18 Homo sapiens 141-149 15066664-6 2004 In comparison to diphenylhydantoin, the novel chloro-substituted alpha-hydroxyphenylamide compounds produced as much as a 20-fold greater tonic and frequency-dependent blockade of Na(V)1.5 channels with an IC(50) value of 14.5 microM. Phenytoin 17-34 immunoglobulin lambda variable 2-18 Homo sapiens 180-188