Pub. Date : 2004 Apr 1
PMID : 15059905
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suppression of Mad2 and BubR1 in paclitaxel-treated cancer cells abolished checkpoint function, resulting in paclitaxel resistance that correlated with suppression of cyclin-dependent kinase-1 activity. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 2 | In contrast, overexpression of Mad2 in cells with a checkpoint defect attributable to low Mad2 expression restored checkpoint function, resulting in enhanced paclitaxel sensitivity that correlated with enhanced cyclin-dependent kinase-1 activity. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |