Title : Tyrosine phosphorylation-dependent activation of NFkappaB is compromised in T cells from the elderly.

Pub. Date : 2004 Apr

PMID : 15050291






1 Functional Relationships(s)
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1 Lowered tyrosine phosphorylation of IkappaBalpha may be due to a decrease in activity of p56(lck) and ZAP-70, since treatment with piceatannol, an inhibitor of syk and src family kinases, mimics age associated decline in tyrosine phosphorylation of IkappaBalpha in T cells from young donors. 3,3',4,5'-tetrahydroxystilbene spleen associated tyrosine kinase Homo sapiens