PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15047839-0	2004	Early activation of the Kaposi"s sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway.	Tetradecanoylphorbol Acetate	99-128	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	137-140	
15047839-5	2004	Treatment with TPA proved to significantly induce both AP1 DNA-binding activity and levels of activated phosphorylated cJUN in PEL cells and ectopic expression of cJUN-plus-cFOS-induced RTA protein expression in PEL cells.	Tetradecanoylphorbol Acetate	15-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-58	
15047839-5	2004	Treatment with TPA proved to significantly induce both AP1 DNA-binding activity and levels of activated phosphorylated cJUN in PEL cells and ectopic expression of cJUN-plus-cFOS-induced RTA protein expression in PEL cells.	Tetradecanoylphorbol Acetate	15-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	119-123	
15047839-5	2004	Treatment with TPA proved to significantly induce both AP1 DNA-binding activity and levels of activated phosphorylated cJUN in PEL cells and ectopic expression of cJUN-plus-cFOS-induced RTA protein expression in PEL cells.	Tetradecanoylphorbol Acetate	15-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	163-167	
15047839-6	2004	Cotransfected cJUN plus cFOS or TPA treatment transactivated the KSHV RTA, RAP, and MTA promoters in an AP1-binding site-dependent manner in all three promoters.	Tetradecanoylphorbol Acetate	32-35	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	104-107	
15047839-7	2004	Chromatin immunoprecipitation assays confirmed that cJUN associates with these KSHV target promoters in PEL cells as early as 4 h after TPA treatment.	Tetradecanoylphorbol Acetate	136-139	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-56	
15047839-9	2004	Both increased phosphorylated cJUN and AP1 DNA-binding activity was detected as early as 1 h after TPA treatment in PEL cells, suggesting that AP1 activity may be crucial for very early activation of the RAP, MTA, and RTA promoters during the KSHV lytic cycle.	Tetradecanoylphorbol Acetate	99-102	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-34	
15047839-9	2004	Both increased phosphorylated cJUN and AP1 DNA-binding activity was detected as early as 1 h after TPA treatment in PEL cells, suggesting that AP1 activity may be crucial for very early activation of the RAP, MTA, and RTA promoters during the KSHV lytic cycle.	Tetradecanoylphorbol Acetate	99-102	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-42	
15047839-9	2004	Both increased phosphorylated cJUN and AP1 DNA-binding activity was detected as early as 1 h after TPA treatment in PEL cells, suggesting that AP1 activity may be crucial for very early activation of the RAP, MTA, and RTA promoters during the KSHV lytic cycle.	Tetradecanoylphorbol Acetate	99-102	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	143-146	
15047839-11	2004	Therefore, we suggest that the initiating effects of TPA via the AP1 pathway in PEL cells need to be amplified by RTA for full lytic-cycle induction.	Tetradecanoylphorbol Acetate	53-56	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-68