Pub. Date : 2004 Apr
PMID : 15039302
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to determine the structure-activity relationships for hPXR-mediated transactivation by barbiturates, hydantoins, and macrolide antibiotics. | Hydantoins | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 2 | In the case of hydantoins, only mephenytoin and ethotoin, which have an alkylchain at the R1-position, strongly activated hPXR at 300 microM. | Hydantoins | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 3 | These results suggest that the presence of an alkyl-chain at the R1-position and the presence of bulky and hydrophobic moieties at both R2- and R3-positions are important factors for activation of hPXR by hydantoins. | Hydantoins | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |