Title : Inactivation of ERK accelerates erythroid differentiation of K562 cells induced by herbimycin A and STI571 while activation of MEK1 interferes with it.

Pub. Date : 2004 Mar

PMID : 15030167






3 Functional Relationships(s)
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1 Inactivation of ERK accelerates erythroid differentiation of K562 cells induced by herbimycin A and STI571 while activation of MEK1 interferes with it. herbimycin mitogen-activated protein kinase 1 Homo sapiens
2 Herbimycin A and STI571 differentiated K562 cells accompanying with the transient down-regulated ERK. herbimycin mitogen-activated protein kinase 1 Homo sapiens
3 These results demonstrate that the erythroid differentiation of K562 cells induced by herbimycin A or STI571 requires the down-regulation of MEK1/ ERK pathway. herbimycin mitogen-activated protein kinase 1 Homo sapiens