Title : A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation.

Pub. Date : 2004 Mar 15

PMID : 15026354






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1 A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation. benzyl isothiocyanate BCL2 apoptosis regulator Homo sapiens
2 We reported here for the first time that the antiapoptotic Bcl-2 protein was phosphorylated by the BITC treatment without significant alteration of the Bcl-2 total protein amount. benzyl isothiocyanate BCL2 apoptosis regulator Homo sapiens
3 Moreover, the spontaneous phosphorylation of antiapoptotic Bcl-2 in the G(2)-M synchronized cells was enhanced synergistically by the BITC treatment. benzyl isothiocyanate BCL2 apoptosis regulator Homo sapiens