Title : alpha-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain.

Pub. Date : 2004 Apr

PMID : 15020070






5 Functional Relationships(s)
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1 alpha-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain. alpha-Tocopherol interleukin 6 Mus musculus
2 The purpose of this study was to determine if alpha-tocopherol-a reactive oxygen species (ROS) scavenging agent-inhibits LPS-induced oxidative stress and interleukin-6 (IL-6) production in murine microglia and brain. alpha-Tocopherol interleukin 6 Mus musculus
3 The purpose of this study was to determine if alpha-tocopherol-a reactive oxygen species (ROS) scavenging agent-inhibits LPS-induced oxidative stress and interleukin-6 (IL-6) production in murine microglia and brain. alpha-Tocopherol interleukin 6 Mus musculus
4 The LPS-induced increase in ROS and IL-6 was reduced by pretreatment of alpha-tocopherol. alpha-Tocopherol interleukin 6 Mus musculus
5 Importantly, three daily injections (20 mg) of alpha-tocopherol increased brain alpha-tocopherol and decreased LPS-induced lipid peroxidation and IL-6 in brain. alpha-Tocopherol interleukin 6 Mus musculus