Title : Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway.

Pub. Date : 2004 Apr 1

PMID : 15013846






5 Functional Relationships(s)
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1 Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway. Flavonols mitogen-activated protein kinase 1 Homo sapiens
2 Western blot studies confirmed that ERK is rapidly activated in cells treated by both flavonols. Flavonols mitogen-activated protein kinase 1 Homo sapiens
3 The data presented in this study support the conclusion that, in MG-63 osteoblasts (i) the increase in ALP activity by flavonols involves a rapid stimulation of ERK activation but also involves the ER, and that (ii) the activation of ERK by flavonols occurs most likely downstream of the ERs activation. Flavonols mitogen-activated protein kinase 1 Homo sapiens
4 The data presented in this study support the conclusion that, in MG-63 osteoblasts (i) the increase in ALP activity by flavonols involves a rapid stimulation of ERK activation but also involves the ER, and that (ii) the activation of ERK by flavonols occurs most likely downstream of the ERs activation. Flavonols mitogen-activated protein kinase 1 Homo sapiens
5 The data presented in this study support the conclusion that, in MG-63 osteoblasts (i) the increase in ALP activity by flavonols involves a rapid stimulation of ERK activation but also involves the ER, and that (ii) the activation of ERK by flavonols occurs most likely downstream of the ERs activation. Flavonols mitogen-activated protein kinase 1 Homo sapiens