Pub. Date : 2004 Apr 1
PMID : 15013846
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway. | Flavonols | mitogen-activated protein kinase 1 | Homo sapiens |
2 | Western blot studies confirmed that ERK is rapidly activated in cells treated by both flavonols. | Flavonols | mitogen-activated protein kinase 1 | Homo sapiens |
3 | The data presented in this study support the conclusion that, in MG-63 osteoblasts (i) the increase in ALP activity by flavonols involves a rapid stimulation of ERK activation but also involves the ER, and that (ii) the activation of ERK by flavonols occurs most likely downstream of the ERs activation. | Flavonols | mitogen-activated protein kinase 1 | Homo sapiens |
4 | The data presented in this study support the conclusion that, in MG-63 osteoblasts (i) the increase in ALP activity by flavonols involves a rapid stimulation of ERK activation but also involves the ER, and that (ii) the activation of ERK by flavonols occurs most likely downstream of the ERs activation. | Flavonols | mitogen-activated protein kinase 1 | Homo sapiens |
5 | The data presented in this study support the conclusion that, in MG-63 osteoblasts (i) the increase in ALP activity by flavonols involves a rapid stimulation of ERK activation but also involves the ER, and that (ii) the activation of ERK by flavonols occurs most likely downstream of the ERs activation. | Flavonols | mitogen-activated protein kinase 1 | Homo sapiens |