Title : Manganese potentiates lipopolysaccharide-induced expression of NOS2 in C6 glioma cells through mitochondrial-dependent activation of nuclear factor kappaB.

Pub. Date : 2004 Mar 30

PMID : 15010209






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Exposure of C6 glioma cells to lipopopolysaccharide (LPS) resulted in increased expression of NOS2 and production of NO that was dramatically potentiated by Mn and was blocked through overexpression of mutant IkappaBalpha (S32/36A). lps nitric oxide synthase 2 Homo sapiens
2 These data indicate that Mn augments LPS-induced expression of NOS2 in C6 cells by increasing mitochondrial ROS and activation of NF-kappaB. lps nitric oxide synthase 2 Homo sapiens