Title : Loss of tyrosinase activity confers increased skin tumor susceptibility in mice.

Pub. Date : 2004 May 20

PMID : 15007389






2 Functional Relationships(s)
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1 In vitro mechanistic studies demonstrated that transfection of the Tyr(Cys) allele in a human squamous cell carcinoma cell line (NCI-H520) increases tyrosinase enzyme activity and confers resistance to hydrogen peroxide-induced oxidative DNA damage. Cysteine tyrosinase Homo sapiens
2 In vitro mechanistic studies demonstrated that transfection of the Tyr(Cys) allele in a human squamous cell carcinoma cell line (NCI-H520) increases tyrosinase enzyme activity and confers resistance to hydrogen peroxide-induced oxidative DNA damage. Cysteine tyrosinase Homo sapiens