Title : Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.

Pub. Date : 2004 Mar 22

PMID : 15006407






1 Functional Relationships(s)
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1 While an electron withdrawing group at the C6-position of the quinoline substantially improved PDE5 potency, an ethyl group at the C8-position not only improved the PDE5 potency but also the isozyme selectivity. quinoline phosphodiesterase 5A Homo sapiens