Title : Dysfunction of endothelial nitric oxide synthase and atherosclerosis.

Pub. Date : 2004 Jun

PMID : 15001455






4 Functional Relationships(s)
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Protein Name
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1 Among various mechanisms implicated in the impaired EDR in atherosclerosis, superoxide generated from dysfunctional eNOS has attracted attention. Superoxides nitric oxide synthase 3, endothelial cell Mus musculus
2 Under conditions in which vascular tissue levels of tetrahydrobiopterin (BH4), a cofactor for NOS, are deficient or lacking, eNOS becomes dysfunctional and produces superoxide rather than NO. Superoxides nitric oxide synthase 3, endothelial cell Mus musculus
3 In contrast, eNOS overexpression with hypercholesterolemia may promote atherogenesis via increased superoxide generation from dysfunctional eNOS. Superoxides nitric oxide synthase 3, endothelial cell Mus musculus
4 In contrast, eNOS overexpression with hypercholesterolemia may promote atherogenesis via increased superoxide generation from dysfunctional eNOS. Superoxides nitric oxide synthase 3, endothelial cell Mus musculus