Title : Mice lacking neuronal nicotinic acetylcholine receptor beta4-subunit and mice lacking both alpha5- and beta4-subunits are highly resistant to nicotine-induced seizures.

Pub. Date : 2004 Apr 13

PMID : 14996991






2 Functional Relationships(s)
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1 Using transgenic mice with mutations in nAChR subunits, it was demonstrated previously that the alpha4-, alpha5-, and alpha7-subunits are involved in nicotine-induced seizures. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 We also generated mice with double deficiency of both alpha5- and beta4-nAChR subunits and demonstrated that they were more resistant to nicotine"s convulsant effect than either the alpha5 or the beta4 single mutant mice. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus