Title : Chloroquine protects mice from challenge with CpG ODN and LPS by decreasing proinflammatory cytokine release.

Pub. Date : 2004 Feb

PMID : 14996414






2 Functional Relationships(s)
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1 We found that 30 mg/kg of CQ could protect mice from lethal challenge by CpG ODN and LPS, and 25 mg/kg of CQ could decrease serum TNF-alpha and IL-6 in rats injected with sublethal doses of CpG ODN and LPS. Chloroquine interleukin 6 Mus musculus
2 In addition, treatment of murine macrophage ANA-1 cells with 2 mM CQ potently inhibited the release of TNF-alpha, IL-6 and IL-12 induced by CpG ODN and LPS. Chloroquine interleukin 6 Mus musculus