Pub. Date : 2004 Mar 19
PMID : 14987951
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of protein tyrosine kinases in CYP1A1 induction by omeprazole and thiabendazole in rat hepatocytes. | Omeprazole | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 2 | Benzimidazoles compounds like omeprazole (OME) and thiabendazole (TBZ) mediate CYP1A1 induction differently from classical aryl hydrocarbon receptor (AhR) ligands, 3-methylcholanthrene (3-MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). | Omeprazole | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 3 | Benzimidazoles compounds like omeprazole (OME) and thiabendazole (TBZ) mediate CYP1A1 induction differently from classical aryl hydrocarbon receptor (AhR) ligands, 3-methylcholanthrene (3-MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). | Omeprazole | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 4 | To clarify the involvement of an intracellular signal pathway in CYP1A1 induction by OME and TBZ, the TBZ, OME and 3-MC signal-transducing pathways were compared by using specific protein tyrosine kinase inhibitors in primary culture of rat hepatocytes. | Omeprazole | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 5 | The effect of OME and TBZ (75-250 microM) on cytochrome P450 1A1 (CYP1A1) expression was therefore studied in primary cultures of rat hepatocytes after 24 h, 48 h and 72 h of exposure. | Omeprazole | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 6 | The effect of OME and TBZ (75-250 microM) on cytochrome P450 1A1 (CYP1A1) expression was therefore studied in primary cultures of rat hepatocytes after 24 h, 48 h and 72 h of exposure. | Omeprazole | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |