Pub. Date : 2004 Apr
PMID : 14987625
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The hypothesis was tested that drugs that bind RyR or IP3 channels would affect the anesthetic potency of bupivacaine. | Bupivacaine | ryanodine receptor 1, skeletal muscle | Mus musculus |
| 2 | The RyR channel agonists 4-chloro-m-cresol and poly-L-lysine significantly reduced the anesthetic potency of bupivacaine. | Bupivacaine | ryanodine receptor 1, skeletal muscle | Mus musculus |
| 3 | Alternatively, the RyR channel antagonist dantrolene sodium dose-dependently increased bupivacaine"s potency. | Bupivacaine | ryanodine receptor 1, skeletal muscle | Mus musculus |
| 4 | Our results indicate that only the RyR channel drugs modulated the anesthetic effects of bupivacaine. | Bupivacaine | ryanodine receptor 1, skeletal muscle | Mus musculus |
| 5 | This provides the first evidence that RyR channels might affect bupivacaine anesthesia in some fashion. | Bupivacaine | ryanodine receptor 1, skeletal muscle | Mus musculus |