PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14987625-4	2004	The hypothesis was tested that drugs that bind RyR or IP3 channels would affect the anesthetic potency of bupivacaine.	Bupivacaine	106-117	ryanodine receptor 1, skeletal muscle	Mus musculus	47-50	
14987625-7	2004	The RyR channel agonists 4-chloro-m-cresol and poly-L-lysine significantly reduced the anesthetic potency of bupivacaine.	Bupivacaine	109-120	ryanodine receptor 1, skeletal muscle	Mus musculus	4-7	
14987625-9	2004	Alternatively, the RyR channel antagonist dantrolene sodium dose-dependently increased bupivacaine"s potency.	Bupivacaine	87-98	ryanodine receptor 1, skeletal muscle	Mus musculus	19-22	
14987625-13	2004	Our results indicate that only the RyR channel drugs modulated the anesthetic effects of bupivacaine.	Bupivacaine	89-100	ryanodine receptor 1, skeletal muscle	Mus musculus	35-38	
14987625-15	2004	This provides the first evidence that RyR channels might affect bupivacaine anesthesia in some fashion.	Bupivacaine	64-75	ryanodine receptor 1, skeletal muscle	Mus musculus	38-41