Title : Null mutant analysis of responses to nicotine: deletion of beta2 nicotinic acetylcholine receptor subunit but not alpha7 subunit reduces sensitivity to nicotine-induced locomotor depression and hypothermia.

Pub. Date : 2004 Feb

PMID : 14982698






2 Functional Relationships(s)
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1 The nicotinic acetylcholine receptor (nAChR) subtypes alpha4beta2 and alpha7 comprise the majority of brain nicotine-binding sites. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 Following nicotine injection, dose-dependent decreases in body temperature and locomotor activity were observed for all three genotypes of both beta2 and alpha7 mice. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus