Title : Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice.

Pub. Date : 2004 Mar 1

PMID : 14980699






1 Functional Relationships(s)
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1 We demonstrate here that a subset of mice with partial deficiency of the mitochondrial superoxide dismutase (Sod2(-/+)) show increased incidence of spontaneous and handling-induced seizures that correlates with chronic mitochondrial oxidative stress (increased aconitase inactivation and 8-hydroxy-2"-deoxyguanosine formation in mitochondria) and diminished mitochondrial oxygen utilization. Superoxides superoxide dismutase 2, mitochondrial Mus musculus