Pub. Date : 2004 Mar 12
PMID : 14975762
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Doxorubicin depletes cardiac p300, a transcriptional coactivator that is required for the maintenance of the differentiated phenotype of cardiac myocytes. | Doxorubicin | E1A binding protein p300 | Mus musculus |
| 2 | Transgenic mice overexpressing p300 in the heart and wild-type mice were subjected to doxorubicin treatment. | Doxorubicin | E1A binding protein p300 | Mus musculus |
| 3 | These findings demonstrate that overexpression of p300 protects cardiac myocytes from doxorubicin-induced apoptosis and reduces the extent of acute heart failure in adult mice in vivo. | Doxorubicin | E1A binding protein p300 | Mus musculus |