Title : Spontaneous nucleotide exchange in low molecular weight GTPases by fluorescently labeled gamma-phosphate-linked GTP analogs.

Pub. Date : 2004 Mar 2

PMID : 14973186






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We show that three guanosine 5"-triphosphate analogs with BODIPY fluorophores coupled via the gamma phosphate bind to the GTPases Cdc42, Rac1, RhoA, and Ras and displace guanosine 5"-diphosphate with high intrinsic exchange rates in the presence of Mg(2+) ions, thereby acting as synthetic, low molecular weight guanine nucleotide exchange factors. Guanosine Diphosphate cell division cycle 42 Homo sapiens