Title : Human cardiac phospholipase D activity is tightly controlled by phosphatidylinositol 4,5-bisphosphate.

Pub. Date : 2004 Feb

PMID : 14871550






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Neomycin, a high-affinity ligand of PIP2, inhibited PLD activity in human atrial myocardium, but had no effect on the activity of partially solubilized enzyme. Neomycin glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
2 The addition of PIP2 restored the sensitivity of solubilized PLD to neomycin inhibition, indicating that neomycin inhibits PLD activity by binding to endogenous PIP2. Neomycin glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
3 The addition of PIP2 restored the sensitivity of solubilized PLD to neomycin inhibition, indicating that neomycin inhibits PLD activity by binding to endogenous PIP2. Neomycin glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
4 The addition of PIP2 restored the sensitivity of solubilized PLD to neomycin inhibition, indicating that neomycin inhibits PLD activity by binding to endogenous PIP2. Neomycin glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens