Pub. Date : 2004 Feb 17
PMID : 14766991
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: reversal by tianeptine. | tianeptine | solute carrier family 1 member 2 | Rattus norvegicus |
| 2 | We also examined the ability of the antidepressant tianeptine, which blocks CRS-induced dendritic remodeling, to modulate CRS-mediated changes in GLT-1 and GLT-1b expression. | tianeptine | solute carrier family 1 member 2 | Rattus norvegicus |
| 3 | We also examined the ability of the antidepressant tianeptine, which blocks CRS-induced dendritic remodeling, to modulate CRS-mediated changes in GLT-1 and GLT-1b expression. | tianeptine | solute carrier family 1 member 2 | Rattus norvegicus |
| 4 | CRS increased GLT-1 mRNA expression in the dentate gyrus and CA3 region of Ammon"s horn, increases that were inhibited by tianeptine. | tianeptine | solute carrier family 1 member 2 | Rattus norvegicus |
| 5 | CRS more selectively increased GLT-1 protein levels in the subregion where dendritic remodeling is most prominent, namely the CA3 region, increases that were also inhibited by tianeptine administration. | tianeptine | solute carrier family 1 member 2 | Rattus norvegicus |
| 6 | These results point to the importance of understanding the mechanism for the differential and subregional regulation of GLT-1 isoforms in neuronal and glial compartments in the hippocampus as a basis for understanding the effects of chronic stress on structural plasticity as well as the neuroprotective properties of agents such as tianeptine. | tianeptine | solute carrier family 1 member 2 | Rattus norvegicus |